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KMID : 1143920220260010098
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Annals of Hepato-Biliary-Pancreatic Surgery
2022 Volume.26 No. 1 p.98 ~ p.103
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Clinical application of a new hemostatic material using mussel-inspired catecholamine hemostat: A pilot study
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Park Young-Mok
Seo Hyung-Il
Kim Jae-Hoon
Yoon Sung-Pil
Lee Hae-Shin
Lee Moon-Sue
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Abstract
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Backgrounds/Aims: This study aimed to evaluate clinical application of InnoSEAL Plus (a mussel-inspired catecholamine hemostat) as a new hemostatic material for humans.
Methods: Patients treated with topical hemostatic patches after liver resection were enrolled. They were divided into an experimental group (InnoSEAL Plus group) and two control groups (TachoSil® group and Surgicel Fibrillar® group) for efficacy evaluation.
Results: A total of 15 patients were enrolled. Each group had five patients. The 3-minute hemostasis success rate was 80.0% (4/5 patients) in the InnoSEAL Plus group, 80.0% (4/5 patients) in the TachoSil® group, and 40.0% (2/5 patients) in the Surgicel Fibrillar® group, showing no significant difference in the success rate among these groups (p > 0.05). All three groups exhibited 100% success rate for 10-minute hemostasis. Both InnoSEAL Plus and TachoSil® groups had one patient developing adverse events, which were treated easily with drug administrations.
Conclusions: InnoSEAL Plus is expected to be functionally not inferior to other conventional hemostatic agents. However, it is necessary to confirm this through multicenter prospective studies in the future.
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KEYWORD
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Pilot study, Hemostatics, Hepatectomy, Mussel adhesion
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